Описание
В учебном пособии описаны теоретические положения и прикладные аспекты биотрансформации ксенобиотиков и лекарств в организме. Рассмотрены виды и фазы биотрансформации и их значение в обезвреживании разнообразных токсических веществ.
Особые разделы посвящены разбору роли системы биотрансформации в метаболизме
и взаимодействии лекарственных средств и проблеме некоторых видов фармакорезистентности. Для оценки усвоения информации представлены тестовые задания.
Предназначено для студентов фармацевтического факультета международного медицинского образования по специальности 33.05.01 «Фармация».
The given course book is compiled in accordance with the Federal State Educational Standard of Higher Education, recommended by the Ministry of Health of the Russian Federation
for Medical universities. The course book contains sections corresponding to the “metabolism
of xenobiotics”, as well as test tasks, related to interactive forms of learning. Special sections
are devoted to the analysis of the role of the biotransformation system in the metabolism and
interaction of drugs and the problem of some types of drug resistance.
The course book is designed to be used in educational institutions that implement the basic
professional educational programs of higher education at the level of a specialist in the field
of training 33.05.01 “Pharmacy”.
CONTENT
Preface…………………………………………………………………………..7
I. INTRODUCTION. Xenobiotics. Basic Concept…………………..9
II. BIOTRANSFORMATION AS A MECHANISM
TO NEUTRALIZE TOXIC SUBSTANCES ………………………………… 19
2.1. Biotransformation. Basic concepts…………………………….. 19
2.2. Microsomal oxidation system …………………………………… 21
2.3. Conjugation as second phase of neutralization
of substances………………………………………………………………. 30
2.4. Clinical evaluation of the biotransformation process …… 38
2.5. Nonmicrosomal biotransformation …………………………… 40
2.6. Effects of chemical modification of xenobiotic molecules….41
2.7. Regulation of biotransformation processes in the body …..45
III. DRUG BIOTRANSFORMATION
IN PHARMACOTHERAPY …………………………………………………… 48
3.1. The basics of pharmacokinetics and pharmacotherapy
of drugs……………………………………………………………………….. 48
3.2. Role of biotransformation system in metabolism
and drug interaction………………………………………………………….. 51
Conclusion…………………………………………………………………… 57
Multiple Choice Test……………………………………………………… 58
Answers ………………………………………………………………………. 64
References …………………………………………………………………… 65
